Study Finds High Degree of Precision Achieved with Light Adjustable Lens

One key to the LAL’s success, according to the researchers, is that surgically induced astigmatism is easily neutralized during the adjustment period, negating this effect while also simplifying the surgical prep by eliminating the need for a toric IOL. Photo: RxSight. Click image to enlarge. The Light Adjustable Lens (LAL, RxSight) is unique in that its final lens power can be adjusted after implantation using ultraviolet (UV) light to meet patients’ visual needs. Recently, results from a Phase IV clinical registry study on the LAL were published in Journal of Cataract & Refractive Surgery.A total of 1,101 subjects (2,202 eyes) across 126 sites were enrolled in this post-marketing (so-called “Phase IV”) study. Besides undergoing IOL implantation, patients were selected if they had a best-corrected distance visual acuity (CDVA) ≥20/20-2 after implantation prior to having their lens adjusted. Clinicians observed results when patients returned within one to three months of adjustment.Subjects were divided into two groups based on whether they had undergone corneal refractive surgery in the past. Five hundred and eighty-six eyes had a prior surgery, while the remaining 1,616 had none. Furthermore, from the overall population, patients with bilateral emmetropia (12.3%), bilateral near (9.3%) and blended vision (78.4%) were examined.Among the two groups (prior surgery and no prior surgery), no significant difference was discovered across all outcome measures. For instance, binocular uncorrected near visual acuity (UNVA) of ≥J1 was achieved with blended vision in 82% of patients with prior surgery and 85% of patients without.According to the team’s paper, a total of 67% of participants opted to have a change in the target refraction induced during the adjustment period, with a mean change of -0.22 ±0.45 (range -2.50D to +1.50D) from the first adjustment target to the final target.Overall, 81.2% of eyes targeted for emmetropia managed to achieve an uncorrected distance visual acuity (UDVA) of ≥20/20. An uncorrected visual acuity of ≥20/20 was achieved in 89% of patients with blended vision and 93% with bilateral emmetropia.In the study, “postoperative UDVA and UNVA are improved compared to historical series using traditional IOLs with fixed power,” wrote the researchers in the paper. “Eyes with no history of corneal refractive surgery and eyes that have undergone corneal refractive surgery achieved similar refractive and visual outcomes, which suggests that the LAL may be particularly useful in patients with prior corneal refractive surgery.”Click here for the journal source. Schallhorn J, Rajanala A. Clinical outcomes of patients bilaterally implanted with the Light Adjustable Lens: Results of a Phase IV clinical registry. JCRS. June 16, 2026. [Epub ahead of print]. This article was developed by the editorial staff in conjunction with experts in the field. In the process, AI may have been among the editorial tools used to meet the goals of human editors, who approved all content.