Regeneron announces FDA issues CRL for aflibercept 8 mg (Eylea HD) sBLA

Published on April 21, 2025
The FDA did not agree with a supplemental Biologics License Application for the addition of extended dosing intervals of up to 24 weeks across currently-approved indications.
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Optical Density Ratio of Intraretinal Fluid a Possible Prognostic Tool for VA in AMD

April 21, 2025
Eyes of wet AMD patients with higher optical density ratio values of intraretinal fluid from OCT were less likely to have a deterioration in BCVA over 36 months of follow up. This image from an older study shows a comparison of an ellipsoid form within subretinal fluid and a second form of the same dimensions within the vitreous.  Photo: Ahlers C, et al. Invest Ophthalmol Vis Sci 2009;50:3417-24. 

Visual impairment, age-related eye disease, and sleep dysfunction in older adults

April 21, 2025
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